Table 1. Association of selected upstream FGB polymorphisms with fibrinogen-related phenotypes.
| Genotype | FGB-rs7439150δ | FGB-rs1800789δ | FGB-rs1800790 | FGB-rs4463047 | |
|---|---|---|---|---|---|
| SNP pseudonym | FGB-1420 G>A | FGB-455 G>A | |||
| Minor allele frequency (%) | A = 6.95 | A = 6.78 | A = 3.32 | T = 11.4 | |
| Genotype group size (n) | major allele hz minor allele carrier |
GG1 (1548) GA/AA2 (215) |
GG1 (1513) GA/AA2 (292) |
GG1 (1652) GA/AA2 (108) |
CC1 (1424) CT/TT2 (357) |
|
Total fibrinogen (g/L) |
major allele hz | 3.66 ± 2.13 | 3.64 ± 2.12 * | 3.66 ± 2.12 | 3.71 ± 2.18 |
| minor allele carrier | 3.97 ± 2.29 | 3.96 ± 2.29 * | 4.05 ± 2.34 | 3.52 ± 1.99 | |
|
Fibrinogen γ' (mg/mL) |
major allele hz | 0.37 ± 0.25* | 0.38 ± 0.25 | 0.38 ± 0.26 * | 0.38 ± 0.27 |
| minor allele carrier | 0.41 ± 0.32* | 0.42 ± 0.33 | 0.46 ± 0.37 * | 0.37 ± 0.22 | |
|
Fibrinogen γ' (%) |
major allele hz | 12.1 ± 8.07 | 12.3 ± 8.27 | 12.1 ± 8.01 | 12.1 ± 8.27 |
| minor allele carrier | 11.6 ± 8.82 | 11.6 ± 7.80 | 13.2 ± 10.1 | 12.2 ± 7.90 | |
|
Lag time (min) |
major allele hz | 6.47 ± 1.97 | 6.47 ± 1.96 | 6.48 ± 1.99 | 6.47 ± 1.97 |
| minor allele carrier | 6.59 ± 1.96 | 6.55 ± 1.99 | 6.49 ± 1.98 | 6.52 ± 1.98 | |
|
Slope (x10−3 au/s) |
major allele hz | 9.58 ± 4.42 | 9.54 ± 4.35 | 9.65 ± 4.36 | 9.67 ± 4.41 |
| minor allele carrier | 10.0 ± 3.99 | 10.3 ± 4.09 | 9.75 ± 3.95 | 9.60 ± 4.32 | |
|
Maximum absorbance (nm) |
major allele hz | 0.43 ± 1.59 * | 0.43 ± 0.16 * | 0.43 ± 0.16 | 0.43 ± 0.16 |
| minor allele carrier | 0.46 ± 0.17 * | 0.46 ± 0.17 * | 0.46 ± 0.19 | 0.44 ± 0.16 | |
|
Clot lysis time (min) |
major allele hz | 56.9 ± 11.2 | 56.8 ± 11.2 *# | 57.0 ± 11.3 | 57.3 ± 11.3 |
| minor allele carrier | 58.0 ± 12.0 | 58.3 ± 12.1 *# | 58.7 ± 11.1 | 56.3 ± 11.3 |
A = adenine; C = cytosine; FGB = fibrinogen beta chain gene; G = guanine; rs = reference sequence; T = thymine; Lag time = time required for the activation of the coagulation cascade by TF and for protofibrils to reach sufficient length to allow lateral aggregation; Slope = rate of lateral aggregation of fibrin protofibrils; Maximum absorbance = indicator of fibre diameter.
Data presented as mean ± SD.
*p < 0.05
# p < 0.05 upon adjustment for total and γ’ fibrinogen
δ Strong evidence of LD (r2 = 0.89; D’ = 0.95).
Age, gender, BMI, HIV-status, HbA1c and HDL-c were covariates. Associations with CLT were adjusted for PA-I1act additionally.