Table 2. Outcome phenotypes descriptive statistics and association with IL-6- quartiles.
| Variable | Whole group (n) |
Interleukin-6 quartiles (pg/mL) | p-value unadjusted (adjusted) | |||
|---|---|---|---|---|---|---|
| Quartile 1 > 0.76 |
Quartile 2 1.50–2.84 |
Quartile 3 2.85–5.75 |
Quartile 4 5.76–424 |
|||
|
Total fibrinogen (g/L) |
3.69 ± 2.18 (1593) |
3.02 ± 1.62 ab | 3.32 ± 1.86 cd | 3.95 ± 2.17 ace | 4.53 ± 2.66 bde | <0.001 |
|
Fibrinogen γ' (mg/L) |
0.38 ± 0.27 (1591) |
0.32 ± 0.22 ab | 0.36 ± 0.25 c | 0.39 ± 0.21 ad | 0.46 ± 0.37 bcd | <0.001 |
|
Fibrinogen γ' (%) |
12.1 ± 8.25 (1527) |
12.5 ± 8.56 | 12.4 ± 7.58 | 11.8 ± 7.77 | 11.8 ± 8.94 | 0.552 |
|
Lag time (min) |
6.46 ± 1.97 (1480) |
6.24 ± 1.99 a | 6.46 ± 2.03 | 6.64 ± 1.93 a | 6.38 ± 1.94 | 0.033 (0.126) |
|
Slope (x10−3 au/s) |
9.70 ± 4.42 (1492) |
9.19 ± 3.80 a | 9.60 ± 4.37 | 9.86 ± 4.30 | 10.5 ± 5.15 a | <0.001 (0.897) |
|
Maximum absorbance (nm) |
0.43 ± 0.16 (1445) |
0.41 ± 0.14 ab | 0.43 ± 0.15 | 0.45 ± 0.15 a | 0.45 ± 0.18 b | <0.001 (0.183) |
|
CLT (min) |
57.3 ± 11.2 (1591) |
58.3 ± 10.8 1 | 56.9 ± 10.9 | 56.8 ± 11.5 | 56.2 ± 11.9 1 | 0.066 (0.002) |
Data presented as mean ± SD
Adjusted p-value = adjusted for total and γ’ fibrinogen; CLT = clot lysis time; Lag time = time required for the activation of the coagulation cascade by TF and for protofibrils to reach sufficient length to allow lateral aggregation; Slope = rate of lateral aggregation of fibrin protofibrils; Maximum absorbance = indicator of fibre diameter.
abcde Means with the same symbol differ significantly for individual outcome variables
1 Means with the same numerical value differ significantly for individual outcome variables upon adjustment.