Table 3. Genotype-IL-6 interactions modulating total fibrinogen concentrations.
| Phenotype | Gene | IL-6 interaction with SNP | Interaction p-value |
Major allele homozygotes | Heterozygotes or minor allele carriers (where only two groups) |
Minor allele homozygotes (where three groups) |
||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | Slope* (95% CI) | n | Slope* (95% CI) | n | Slope* (95% CI) | |||||
|
Total fibrinogen (g/L) |
FGB | rs7439150δ | 0.001 | GG | 1293 | 0.015 (0.009–0.020) | 174 | 0.072 (0.040–0.104) | ||
| FGB | rs1800789δ | <0.001 | GG | 1263 | 0.012 (0.006–0.018) | 240 | 0.071 (0.050–0.093) | |||
| FGB | rs1800788 | <0.001 | CC | 1419 | 0.017 (0.012–0.023) | 154 | 0.083 (0.045–0.121) | |||
| FGB | rs1800787δ | 0.001 | CC | 1164 | 0.016 (0.010–0.022) | 152 | 0.077 (0.043–0.111) | |||
| FGB | rs4220 | 0.003 | GG | 1121 | 0.016 (0.010–0.022) | 224 | 0.061 (0.035–0.087) | |||
| FGA | rs6050 | <0.001 | AA | 676 | 0.039 (0.028–0.049) | 526 | 0.016 (0.006–0.027) | 132 | 1 x 10−4(-0.010–0.010) | |
| FGA | rs2070011 | 0.010 | GG | 925 | 0.015 (0.009–0.021) | 416 | 0.042 (0.024–0.060) | |||
| FGG | rs2066865 | <0.001 | CC | 746 | 0.040 (0.029–0.050) | 482 | 0.005 (-0.003–0.012) | 108 | 0.111 (0.067–0.156) | |
| FGG | rs1049636 | <0.001 | TT | 975 | 0.014 (0.008–0.020) | 371 | 0.110 (0.082–0.138) |
A = adenine; C = cytosine; CI = confidence interval; G = guanine; IL-6 = interleukin-6; rs = reference sequence; T = thymine; rs1800789 = -1420G/A; rs1800788 = -249C/T; rs1800787 = -148C/T
rs1800790 = -455G/A; rs2070011 = 2224G/A, rs1049636 = 9340T/C
δVariants in high linkage disequilibrium (r2 > 0.82; D’ > 0.92)
*In the regression line y = mx + c, “slope” refers to m.