Table 4. Genotype-IL-6 interactions modulating clot properties.

Phenotype	Gene	IL-6 interaction with SNP	Interaction p-value				Major allele homozygotes		Heterozygotes or minor allele carriers (where only two groups)		Minor allele homozygotes (where three groups)
			Unadjusted	Adjusted
						n	Slope* (95% CI)	n	Slope* (95% CI)	n	Slope* (95% CI)
Maximum absorbance (nm)	FGB	rs7439150 δ	<0.001	0.01	GG	1274	1x10-4 (-3x10-4–0.001)	179	0.003 (0.002–0.003)
	FGB	rs1800789 δ	<0.001	0.82	GG	1245	2x10-4 (-3x10-4–0.001)	241	0.002 (0.002–0.003)
	FGB	rs1800788	0.001	0.04	CC	1407	0.001 (2x10-4–0.001)	153	0.004 (0.002–0.007)
	FGB	rs1800787 δ	<0.001	0.01	CC	1157	1x10-4 (-3x10-4–0.001)	157	0.003 (0.002–0.003)
	FGA	rs6050	0.001	0.04	AA	663	-1x10-5 (-0.001–0.001)	531	0.002 (0.001–0.002)	133	1x10-5(-0.001–0.001)
	FGG	rs1049636	0.003	0.23	TT	970	0.001 (3x10-4–0.001)	369	0.003 (0.001–0.005)

A = adenine; C = cytosine; CI = confidence interval; G = guanine; IL-6 = interleukin-6; rs = reference sequence; T = thymine; rs1800789 = -1420_G/A; rs1800788 = -249_C/T; rs1800787 = -148_C/T; rs1049636 = 9340_T/C

Adjusted = adjusted for total fibrinogen (g/L); Slope = rate of lateral aggregation of fibrin protofibrils; Maximum absorbance = indicator of fibre diameter.

^δVariants in high linkage disequilibrium (r² > 0.82; D’ > 0.92)

*In the regression line y = mx + c, “slope” refers to m.