Table 1. Disease-related parameters—Estimated values and ranges used in sensitivity analysis.

Parameter	Value	Range	Source/Comments
Transmission constant (T)	5.1		Calibrated to match incidence rates of first infection at 6, 12, 24, 36 months as reported by Gladstone[28]
Efficacy of kth (k = 1, 2, 3) natural infection against any future infection (γk)	0.39, 0.52, 0.67	Low: 0.29, 0.43, 0.59 High: 0.47, 0.59, 0.74	[28]
Decreased infectiousness of second infection	0.5	0.3, 0.7	[29, 30]
Decreased infectiousness of third, fourth infection	0.2	0, 0.4	[29, 30]
Mean duration of infection (days)	7	4, 10	[25, 31]
Probability that kth (k = 1, 2, 3, 4) infection will cause symptoms given no vaccination (αk)	0.413, 0.349, 0.235, 0.201	± 50%	[28]
Probability that symptoms of kth (k = 1, 2, 3, 4) infection will be severe[34]* if present (βk)	0.153, 0.221, 0.233, 0.167	± 50%	[28]
Probability of dying from severe* rotavirus given no formal treatment	0.061	0.0305, 0.1220	Calibrated to match 5-year Indian rotavirus mortality of 1/242 without vaccination[32]
Waning of protection of maternal antibodies	Protection declines linearly from 100% to 0% between birth and 13 weeks of age		[33]

* Severe infections are defined as those with a Vesikari score > = 11.