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. 2017 Nov 3;12(11):e0187446. doi: 10.1371/journal.pone.0187446

Table 2. Vaccine-related parameters–Estimated values and ranges used in sensitivity analysis.

Parameters Value Range4 Comments/Questions
Dose 1 coverage (6 weeks) 0.88 0.66, 1 [35]
Dose 2 coverage (10 weeks) 0.80 0.60, 1 [35]
Dose 3 coverage (14 weeks) 0.72 0.54, 0.9 [35]
Efficacy of vaccine against severe infection (δsev) 0.536 0.35, 0.669 [15]
Efficacy of vaccine against symptomatic infection (δsx) 0.346 0.216, 0.453 [15]
Efficacy of vaccine against any infection (δany) 0.304 0.1988, 0.38 Based on ratio of efficacy of prior natural infection against any infection to efficacy of prior natural infection against severe infection[28]
Proportion of efficacy (pd) conferred by d = 0, 1, 2, 3 doses 0, 0.82, 0.84, 1 Low: 0, 0.62, 0.64, 1; High: 0, 1, 1, 1 [36]
Annual rate of waning of vaccine efficacy 0.086 0, 0.2 [8, 37]
Risk of intussusception 0.00003 [38]
Case fatality of intussusception 0.25 Assumption