Table 5. Comparison of beta blocker hepatotoxicity cases.

Reference	Drug	Age (Years)/ Sex	Symptoms, signs and labs	Outcome
					Repeat Exposure
Kootte, et al. [26]	Sotalol	68/Female	Elevated Liver enzymes	Liver functions Normalized in five months after discontinuation of the drug.	Unknown
Hagmeyer and Stein [27]	Carvedilol	40/Male	Pruritis, elevated serum transaminases	Carvedilol was discontinued, symptoms improved with hydroxyzine. The drug was discontinued and liver enzymes improved after three weeks.	One year later, the patient was started on metoprolol and developed pruritus in 10 days and the drug was stopped. Liver enzymes remained normal.
Dumortier, et al. [23]	Atenolol	57/Female	Asthenia and elevated liver enzymes	Liver biopsy showed portal and centrilobular inflammation. After receiving steroids, liver function tests improved but were still elevated; repeat biopsy showed necrosis in centrilobular areas with pigmented macrophages. Liver function tests normalized two months after discontinuation of atenolol. Control liver biopsy in seven months showed disappearance of centrilobular lesions.	No