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. 2017 Jul 31;127(9):3300–3312. doi: 10.1172/JCI86881

Figure 7. Blockade by anti–cadherin-11 mAb in obese WT mice improves glycemic control in obesity.

Figure 7

B6 WT mice were injected i.p. with an anti–cadherin-11–specific Ab (SYN12) or mIgG1 isotype control Ab (10 mg/kg BW) every 3 days for the last 3 weeks of a 9-week HFD (n = 5 ND, n = 7 mIgG1-treated HFD-fed mice, and n = 8 SYN12-treated HFD-fed mice). Data are representative of 3 independent experiments. (A) BW before and after HFD-feeding and fat pad weights. (B) GTT and AUC data. (C–E) qPCR analysis of Il3, Il13, and collagens in adipose tissue. (F) Liver weights. Data are expressed as the mean ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001, by unpaired Student’s t test (A, B for the AUC graph, and C–F) and 2-way ANOVA for mIgG1-treated HFD-fed mice versus SYN12-treated HFD-fed mice (B).