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. 2017 Jul 31;127(9):3527–3542. doi: 10.1172/JCI93488

Figure 6. Atypical HCC containing a rare germline GATA4 mutation.

Figure 6

(A) GATA4 germline missense mutation (V267M) found in 2 of 51 patients (4%). Sanger and targeted deep sequencing of HCC, adjacent nonmalignant liver, and peripheral blood mononuclear cells (Supplemental Figure 7). (B) Frequency of this mutation in healthy individual populations from Singapore (Sing.) and China (34–36) ***P < 0.001, Fisher’s exact test. (C) HCC cases with GATA4 mutation had near-normal karyotype. Karyotype analyzed by SNP array and imaged by IGV. Pathstage, American Joint Committee on Cancer staging system. HepBsAg, hepatitis B surface antigen; Del, GATA4 locus deletion.