Fig. 1.

Tamoxifen induces a decrease in the number of parietal cells (PCs) in the gastric mucosa of mice. (A) Mice were treated with 3 mg/20 g body weight of tamoxifen or vehicle for 3 days. Experimental mice were sacrificed at the indicated time points after the final tamoxifen administration. PCs were counted in hematoxylin and eosin-stained sections. (B) The expression levels of vascular endothelial growth factor (VEGF)-β and GS II were evaluated by confocal microscopy after immunofluorescence staining of deparaffinized tissue sections (red: GS II, a mucosal neck cell marker; green: VEGF-β, a PC marker).

CI, confidence interval.