Table 1.

The Expression Pattern of Cytokines and Their Receptors in the Mouse Stomach 3 Days after Vehicle or Tamoxifen Administration

	Gene symbol	Base mean of control*	Base mean of case†	Fold change
Proinflammatory
IL-1α	IL1A	12.5	24.0	1.92
IL-1β	IL1B	12.0	6.0	0.50
IL-1 receptor	IL1R1	563.5	626.0	1.11
IL-6	IL6	0.0	1.0	NA
IL-6 receptor	IL6RA	205.0	244.5	1.19
IL-12, subunit p35	IL12A	0.0	0.0	NA
IL-12, subunit p40	IL12B	0.0	0.0	NA
IL-12 receptor, subunit β1	IL12RB1	2.0	0.5	0.25
IL-12 receptor, subunit β2	IL12RB2	24.0	22.5	0.94
TNF-α	TNF	1.0	0.5	0.50
TNF receptor	TNFRSF1A	1,965.5	2,068.0	1.05
IFN-γ	INFG	0.0	0.0	NA
IFN-γ receptor	IFNGR1	3,487.5	3,808.5	1.09
IL-17	IL17A	0.0	0.0	NA
IL-17 receptor A	IL17RA	315.0	384.5	1.22
IL-17 receptor C	IL17RC	1,075.5	1,309.5	1.22
IL-21	IL21	0.0	0.0	NA
IL-21 receptor	IL21R	4.5	5.0	1.11
IL-22	IL22	0.0	0.0	NA
IL-22 receptor	IL22RA1	295.0	333.5	1.13
Anti-inflammatory or immune-regulatory
IL-4	IL4	0.5	0.5	1.00
IL-4 receptor	IL4RA	664.0	872.5	1.31
IL-5	IL5	0.68	0.31	0.46
IL-5 receptor, subunit α	IL5RA	0.0	0.5	NA
GM-CSF/IL-3/IL-5 receptor common β subunit	Csf2rb	54.5	42.0	0.77
IL-13	IL13	0.0	0.0	NA
IL-13 receptor, α1	IL13RA1	1,705.0	2,125.0	1.25
IL-10	IL10	2.0	0.5	0.25
IL-10 receptor, subunit α	IL10RA	41.0	41.5	1.01
IL-10 receptor, subunit β	IL10RB	1,224.5	1,348.0	1.10
TGF-β1	TGFB1	173.5	188.5	1.09
TGF-β2	TGFB2	106.5	101.5	0.95
TGF-β3	TGFB3	139.0	114.0	0.82
TGF-β receptor 1	TGFBR1	931.0	937.0	1.01
TGF-β receptor 2	TGFBR2	2,059.5	2,063.5	1.00
TGF-β receptor 3	TGFBR3	630.0	756.0	1.20

IL, interleukin; NA, not available; TNF, tumor necrosis factor; IFN, interferon; GM-CSF, granulocyte macrophage colony-stimulating factor; TGF, transforming growth factor.

^*Base mean of mouse stomachs sacrificed 3 days after vehicle administration;

^†Base mean of mouse stomachs sacrificed 3 days after tamoxifen administration.