Table 2.

Key characteristics of IDH-wt and IDH-mut glioblastomas

	IDH-wt	IDH-mut
Synonym	Primary GBM	Secondary GBM
Precursor lesion	Develops de novo	Diffuse astrocytoma, anaplastic astrocytoma
Proportion of glioblastomas	~90%	~10%
Median age at diagnosis	~62 years	~44 years
Male-to-female ratio	1.42:1	1.05:1
Mean length of clinical history	4 months	15 months
Median survival
Surgery, radiotherapy	9.9 months	24 months
Surgery, radiotherapy, chemotherapy	15 months	31 months
Location	Supratentorial	Preferentially frontal
Necrosis	Extensive	Limited
TERT promoter mutations	72%	26%
TP53 mutations	27%	81%
ATRX mutations	Exceptional	71%
EGFR amplification	35%	Exceptional
PTEN mutations	24%	Exceptional

Table adapted from reference (11).