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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Exp Eye Res. 2017 Aug 18;164:129–138. doi: 10.1016/j.exer.2017.08.012

Figure 2. Laminar disruption of the bipolar and photoreceptor cell layers in the OIR mouse retina in vivo.

Figure 2

Examples of horizontal B-scans from the P42, OIR eye shown en face in Figure-1. Laminar disruptions (black arrows) were detected in the living eye, demonstrating that disruptions and intermixing of nuclei between the inner nuclear layer (INL) and outer nuclear layer (ONL), seen in fixed retinal tissue sections, are not artifacts of histology processing. The numbers of larger disruptions were greater in the inferior retina compared to the superior retina. The optical back-scattering density of tissue disruptions was also greater in the inferior retina. Horizontal B-scan locations shown are (A) superior (y = +0.47mm), (B) central (y = 0.0 mm) and (C) inferior (y = −0.47 mm). The retinal layers visible are labeled: NFL/GCL (nerve fiber layer / ganglion cell layer), IPL (inner plexiform layer), INL/OPL/INL (inner nuclear layer / outer plexiform layer / outer nuclear layer), RPE (retinal pigment epithelium).