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. 2017 Sep 26;102(6):1441–1450. doi: 10.1189/jlb.4A0517-179R

Figure 2. Both hematopoietic and nonhematopoietic MyD88 contribute to inflammatory cytokine protection during infection with type A F. tularensis.

Figure 2.

MyD88fl/fl (control), MyD88−/−, and conditional MyD88-deficient mice (n = 5–8 per group) were infected s.c. with 75 CFU of F. tularensis SchuS4. Four days after infection, splenic cytokine levels of TNF-α (A), IL-1β (B), IL-6 (C), IL-10 (D), CCL-3 (E), IFN-γ (F), IL12p70 (G), IL17 (H), IL-4 (I), and CCL-2 were assayed via multiplex assay or ELISA. Cytokines were also measured in naïve WT spleens (n = 5). Error bars, sem. *P < 0.05 vs. infected MyD88fl/fl mice, by ANOVA followed by Dunnett’s test.