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. 2017 Oct 30;12:7963–7977. doi: 10.2147/IJN.S140573

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© 2017 Wang et al. This work is published and licensed by Dove Medical Press Limited

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Investigation on drug release, pharmacokinetics, and histopathological changes.

Notes: (A) (a) Cumulative release profiles of DPT from DPT-PCM at pH 7.4, pH 6.8, and pH 5.0 (mean ± SD, n=3). *P<0.05 and **P<0.01 as compared to DPT-PM at the same pH. ***P<0.001 as compared to pH 7.4. (b) The profile of the plasma DPT concentration vs time after intravenous administration of 15 mg/kg dose of DPT-PCM and 15 mg/kg dose of DPT-PM (mean ± SD, n=6). (B) Histopathological photograph of an ear vein (scale bar =100 µm).

Abbreviations: DPT, deoxypodophyllotoxin; PCM, polyion complex micelle; PM, polymeric micelle.