Table S1.
Nutrients associated with FEV1/FVC ratio (%) in the LSC and VSCa
| Nutrient (U/day)b | LSC (n=1,829)
|
VSC (n=508)
|
||
|---|---|---|---|---|
| Estimate (SE) | FDR | Estimate (SE) | FDR | |
| Minerals | ||||
| Magnesium (174.7 mg) | 0.732 (0.396) | 0.074 | 2.421 (1.024) | 0.023 |
| Magnesium (144.7 mg)c | 1.256 (0.481) | 0.025 | 2.161 (1.063) | 0.045 |
| Vitamins | ||||
| Total folate intake (478.6 μg) | 1.019 (0.349) | 0.025 | 2.231 (0.775) | 0.009 |
| Folic acid (411.0 μg) | 0.671 (0.325) | 0.048 | 1.858 (0.706) | 0.013 |
| Folate equivalents (860.5 μg) | 0.857 (0.333) | 0.025 | 2.144 (0.741) | 0.009 |
| Niacin (24.8 mg) | 0.374 (0.154) | 0.025 | 1.861 (0.605) | 0.009 |
| Vitamin A (9,160.2 IU) | 0.754 (0.266) | 0.025 | 1.245 (0.534) | 0.023 |
| Vitamin D (468.9 IU) | 0.454 (0.300) | 0.139 | 1.337 (0.765) | 0.081 |
| Fatty acids | ||||
| Eicosenoic fatty acid (135 mg) | 0.638 (0.267) | 0.025 | 1.541 (0.540) | 0.009 |
| EPA (100 mg) | 0.290 (0.121) | 0.025 | 0.740 (0.263) | 0.009 |
| DPA (20 mg) | 0.513 (0.202) | 0.025 | 1.393 (0.405) | 0.009 |
| DHA (150 mg) | 0.456 (0.205) | 0.034 | 1.319 (0.432) | 0.009 |
| EPA + DPA + DHA (310 mg) | 0.460 (0.192) | 0.025 | 1.229 (0.405) | 0.009 |
| EPA + DHA (290 mg) | 0.452 (0.190) | 0.025 | 1.207 (0.404) | 0.009 |
| trans-oleic (1.2 g) | −0.716 (0.559) | 0.20 | −1.847 (0.767) | 0.022 |
| AOAC fiber (10.5 g) | 1.075 (0.403) | 0.025 | 2.018 (0.761) | 0.013 |
Notes: EPA, eicosapentaenoic fatty acid 20:5n3; DPA, docosapentaenoic fatty acid 22:5n3; DHA, docosahexaenoic fatty acid 22:6n3; eicosenoic fatty acid 20:1n9.
IQR is used for calculating the estimate and 95% CI. Association analysis in the LSC was conducted based on longitudinal spirometry data using linear mixed effects model with adjustment for important covariates. Association analysis in the VSC was conducted based on baseline spirometry data using linear regression with adjustment for important covariates.
Assessment of total folate intake and folate equivalents includes all sources (ie, natural food, supplements, and fortified foods). Folic acid is from supplements and fortified foods. A total of 38% study subjects have missing data for trans-oleic fatty acid.
Estimate of intake without counting supplement.
Abbreviations: FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; LSC, Lovelace Smokers cohort; VSC, Veteran Smokers cohort; SE, standard error; FDR, false discovery rate; AOAC, the Association of Official Agricultural Chemists; IQR, interquartile range.