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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Mol Cancer Ther. 2017 Sep 1;16(11):2473–2485. doi: 10.1158/1535-7163.MCT-16-0834

Figure 6. 7rh in combination with chemotherapy reduced Ddr1-mediated signaling and tumorigenicity in a GEMM of PDA.

Figure 6

(A) Schematic representation of the animal experiment. (B–C) 7rh combined with a chemotherapy regimen (gemcitabine + nab-paclitaxel) enhanced the overall median of survival in the KPC GEMM of PDA. (D–J) Immunohistological analyses of PDA tumors demonstrated that 7rh, chemotherapy, and the combination regimen significantly inhibited Ddr1-mediated signaling, the levels of the mesenchymal marker Vimentin and proliferation (Pcna) and induced apoptosis (Cleaved Caspase-3) and DNA damage (ΥH2ax). Error bars: (*, p < 0.05; **, p < 0.005; ***, p < 0.0005; ****, p < 0.00005) compared to the initial group; (^, p < 0.05; ^^, p < 0.005; ^^^, p < 0.0005; ^^^^, p < 0.00005) compared to the vehicle group, one-way ANOVA with Tukey’s MCT.