Table 1.
Description of animal experiments
| Endpoint: | Experiment start | 10 days post tumor cell injection |
| Animals | C57BL/6, (n = 3/group) | |
| Treatment groups | Vehicle: 1 dose | |
| 7rh: 0.1 mg/kg, 1 dose | ||
| 7rh: 1 mg/kg, 1 dose | ||
| 7rh: 10 mg/kg, 1 dose | ||
| Associated figures | Supplementary Figure 1 | |
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| Endpoint: | Experiment start | 10 days post tumor cell injection |
| 7rh titration | Experiment length | 21 days post tumor cell injection |
| Animals | C57BL/6, (n = 5/group) | |
| Treatment groups | Vehicle: 3×/week | |
| 7rh: 3.3 mg/kg, 3×/week | ||
| 7rh: 10 mg/kg, 3×/week | ||
| 7rh: 30 mg/kg, 3×/week | ||
| Associated figures | Supplementary Figures 2–3 | |
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| Endpoint: | Experiment start | 19 days post tumor cell injection |
| 7rh monotherapy | Experiment length | 40 days post tumor cell injection |
| Animals | C57BL/6, (n = 16/group) | |
| Treatment groups | Vehicle: 3×/week | |
| 7rh: 25 mg/kg, 3×/week | ||
| Associated figures | Figure 4 | |
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| Survival: | Experiment start | 27 days post tumor cell injection |
| 7rh +/− chemo | Experiment length | Until moribund |
| Animals | Nod Scid, (n = 12/group) | |
| Treatment groups | Vehicle: 3×/week | |
| 7rh: 25 mg/kg, 3×/week | ||
| Chemotherapy: Gem (12.5 mg/kg, 2×/week), Nab-pac (5 mg/kg, 2×/week) | ||
| Combination: 7rh + chemotherapy | ||
| Associated figures | Figure 5, Supplementary Figure 4 | |
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| Survival: | Experiment start | 16 weeks old |
| 7rh +/− chemo | Experiment length | Until moribund |
| Animals | KPC (LSL-KrasG12D/+; LSL-Trp53R172H/+; P48-Cre), (n = 12/group) | |
| Treatment groups | Vehicle: 3×/week | |
| 7rh: 25 mg/kg, 3×/week | ||
| Chemotherapy: Gem (12.5 mg/kg, 2×/week), Nab-pac (5 mg/kg, 2×/week) | ||
| Combination: 7rh + chemotherapy | ||
| Associated figures | Figure 6, Supplementary Figure 5 | |
Abbreviations: Gem, gemcitabine; Nab-pac, nab-paclitaxel.