Figure 1. ‘ILC-poiesis’ allows for the generation of tissue ILCs ‘on demand’.

1) Local tissue disturbances (infection, inflammation, etc.) are often associated with inflammasome activation and liberation of IL-1β (yellow circles). 2) Circulating ILC precursors (ILCP) are subsequently recruited from blood and 3) stimulated to expand in response to IL-1β. 4) Additional tissue signals then guide appropriate ILC differentiation to combat the inciting event and also result in ILC tissue retention.