Figure 3. SPR analysis of antibodies against TNF-α and IL-17A.

Anti-IL-17A mAb, ant-TNF-α mAb, or bispecific antibody was captured by anti-human Fc antibody on to a CM5 chip. A range of TNF-α (0 nM to 100 nM) and IL-17A (0 nM to 100 nM) were injected over all antibodies. Data was fitted to a 1:1 Langmuir binding model to determine binding parameters.