Table 3. Relationship between ING5 expression and clinicopathological features of the non-basal triple negative breast cancer.
Clinicopathological Features |
n | Nuclear ING5 expression | Cytoplasmic ING5 expression | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
– | + | ++ | +++ | PR(%) | p | – | + | ++ | +++ | PR(%) | p | ||
Age (years) | |||||||||||||
< 45 | 29 | 4 | 7 | 10 | 8 | 86.2 | 0.299 | 0 | 20 | 8 | 1 | 100.0 | 0.484 |
≥ 45 | 139 | 10 | 25 | 62 | 42 | 92.8 | 26 | 63 | 43 | 7 | 81.3 | ||
Tumor size(cm) | |||||||||||||
< 2.5 | 87 | 9 | 18 | 36 | 24 | 89.7 | 18 | 47 | 21 | 1 | 79.3 | ||
≥ 2.5 | 74 | 5 | 14 | 33 | 22 | 93.2 | 0.495 | 7 | 33 | 27 | 7 | 90.5 | 0.001 |
Pathological classification | |||||||||||||
Invasive ductal cancer | 142 | 13 | 27 | 60 | 42 | 90.2 | 0.634 | 21 | 71 | 43 | 7 | 85.2 | 0.136 |
Invasive lobular cancer | 9 | 1 | 2 | 4 | 2 | 88.9 | 4 | 3 | 1 | 1 | 55.6 | ||
Lymphatic vessel invasion | |||||||||||||
+ | 19 | 2 | 3 | 8 | 6 | 89.5 | 0.701 | 1 | 12 | 4 | 2 | 94.7 | 0.569 |
– | 54 | 0 | 14 | 21 | 19 | 100.0 | 9 | 26 | 19 | 0 | 83.3 | ||
Lymph node metastasis | |||||||||||||
+ | 77 | 4 | 15 | 35 | 23 | 94.8 | 0.486 | 11 | 38 | 24 | 4 | 85.7 | 0.426 |
– | 79 | 10 | 14 | 32 | 23 | 87.3 | 15 | 39 | 21 | 4 | 81.0 | ||
TNM Staging | |||||||||||||
I–II | 51 | 10 | 9 | 23 | 9 | 80.4 | 9 | 22 | 15 | 5 | 82.4 | ||
III–IV | 7 | 1 | 0 | 4 | 2 | 85.7 | 0.296 | 2 | 2 | 3 | 0 | 71.4 | 0.727 |
ER expression | |||||||||||||
+ | 104 | 8 | 19 | 50 | 27 | 92.3 | 0.931 | 16 | 52 | 31 | 5 | 84.6 | 0.905 |
– | 49 | 6 | 9 | 19 | 15 | 87.8 | 7 | 26 | 14 | 2 | 85.7 | ||
PR expression | |||||||||||||
+ | 90 | 6 | 16 | 45 | 23 | 93.3 | 0.743 | 14 | 46 | 26 | 4 | 84.4 | 0.800 |
– | 63 | 8 | 12 | 24 | 19 | 87.3 | 9 | 32 | 19 | 3 | 85.7 | ||
Her2 expression | |||||||||||||
+ | 93 | 9 | 17 | 42 | 25 | 90.3 | 0.712 | 15 | 50 | 26 | 2 | 83.9 | 0.201 |
– | 58 | 5 | 10 | 26 | 17 | 91.4 | 8 | 27 | 18 | 5 | 86.2 | ||
p53 expression | |||||||||||||
+ | 63 | 1 | 11 | 25 | 26 | 98.4 | 0.045 | 10 | 33 | 18 | 2 | 84.1 | 0.896 |
– | 32 | 2 | 8 | 15 | 7 | 93.8 | 3 | 20 | 8 | 1 | 90.6 | ||
Ki-67 percentage (%) | |||||||||||||
< 50 | 135 | 13 | 23 | 61 | 38 | 90.4 | 0.771 | 21 | 68 | 41 | 5 | 84.4 | 0.354 |
≥ 50 | 19 | 1 | 4 | 8 | 6 | 94.7 | 2 | 9 | 6 | 2 | 89.5 |
PR , positive rate; TNM, tumor node metastasis; ER, estrogen receptor; PR, progesterone receptor.