Table 3. Univariate and multivariate Cox regression analysis of the clinicopathological characteristics and hematological indexes.
| Univariate Cox regression HR (95%CI) | P | Multivariate Cox regression HR (95%CI) | P | |
|---|---|---|---|---|
| Age | 1.161 (0.774, 1.743) | 0.47 | - | - |
| Gender | 0.606 (0.393, 0.934) | 0.023 | - | - |
| Current smoking | 2.067 (1.365, 3.131) | 0.001 | 1.774* (1.153, 2.731) | 0.009 |
| PS | 1.578 (1.010, 2.465) | 0.045 | - | - |
| Tumor location | 0.714 (0.469, 1.087) | 0.116 | - | - |
| Pathological type | 1.049 (0.613, 1.795) | 0.862 | - | - |
| TNM Stage | 1.544 (0.978, 2.439) | 0.062 | - | - |
| T stage | 1.308 (0.774, 2.210) | 0.316 | - | - |
| N stage | 1.779 (1.154, 2.743) | 0.009 | - | - |
| M stage | 1.792 (1.047, 3.068) | 0.033 | - | - |
| Organ metastasis counts | 1.977 (1.217, 3.210) | 0.006 | 1.732* (1.045, 2.870) | 0.033 |
| Therapy | 0.602 (0.321, 1.129) | 0.114 | - | - |
| CEA | 0.717 (0.479, 1.073) | 0.106 | - | - |
| WBC | 1.228 (0.768, 1.963) | 0.392 | - | - |
| Neutrophil | 1.284 (0.769, 2.146) | 0.339 | - | - |
| Lymphocyte | 1.065 (0.391, 2.9) | 0.902 | - | - |
| NLR | 2.308 (1.443, 3.694) | < 0.0001 | - | - |
| NLMR | 1.521 (0.937, 2.47) | 0.09 | - | - |
| Platelet | 1.244 (0.773, 2.005) | 0.369 | - | - |
| D-dimer | 3.326 (2.028, 5.453) | < 0.0001 | - | - |
| Fg | 2.15 (1.408, 3.282) | < 0.0001 | - | - |
| FDP | 2.949 (1.968, 4.420) | < 0.0001 | - | - |
| RBC | 1.236 (0.778, 1.963) | 0.37 | - | - |
| Hemoglobin | 1.383 (0.913, 2.93) | 0.126 | - | - |
| Albumin | 2.67 (1.708, 4.174) | < 0.0001 | - | - |
| PLR | 1.462 (0.945, 2.264) | 0.088 | - | - |
| PDM | 3.605 (2.397, 5.423) | < 0.0001 | - | - |
| SII | 2.404 (1.603, 3.606) | < 0.0001 | 1.809* (1.178, 2.776) | 0.007 |
| PNI | 3.328 (1.968, 5.628) | < 0.0001 | 2.322* (1.297, 4.118) | 0.010 |
| NLFDPA | 3.759 (2.501, 5.65) | < 0.0001 | - | - |
| NLFgA | 2.167 (1.228, 3.826) | 0.008 | - | - |
| NLDA | 1.701 (1.424, 2.032) | < 0.0001 | 3.038* (1.959, 4.712) | < 0.0001 |
Abbreviations: PS, Performance Status; CEA, carcinoembryonic antigen; WBC, white blood cell; ULN, upper limit of normal; NLR = N/L; NLMR = N/(L+M); Fg, fibrinogen; FDP, fibrin degradation product; RBC, red blood cells; LLN, lower limit of normal; PLR = P/L; PDM = P × D; SII = P × N/L; PNI = albumin + 5 × L; NLFDPA = N × FDP/(L × albumin); NLFgA = N × Fg/(L × albumin); NLDA = N × D/(L × albumin). The linear correlation test has been applied to investigate cox proportional hazards assumption. The variables, occupying statistical significance in Univariate Cox Regression, were analyzed in Multivariate Cox Regression. The interaction terms between those covariates were taken into consideration. * HR had been adjusted.