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. 2017 May 30;8(47):82006–82026. doi: 10.18632/oncotarget.18299

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Copyright: © 2017 Grigorenko et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) C.elegans Ce-IMP-2 protein structure and mutations studied. Functionally important super-conservative sites (D306, GLGD 350-353, PAL 417-419) are indicated in red. (B) The loss-of-function of Ce-imp-2 (homolog of human SPP/hIMP1) leads to two major defects: embryonic death and a larvae death/molting defect (black arrows) [48]. (C, D) Detailed analysis of phenotypes in progeny of Ce-imp-2^+/- (tm1397) and Ce-imp-1^-/-/Ce-imp-2^+/- (tm827×tm1397) strains.