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Co-transfections of wild type or mutant PSEN1 and NotchΔE constructs were performed in PSEN1-/-/PSEN2-/- MEF cells. Cleavage products were detected by C-myc antibody. Histogram shows the percent ratio of NICD to uncleaved NotchΔE. An additional nonspecific band is marked by an asterisk. P-value significance codes: ‘*’ <0.05.
