Table 2. Genetic mutations and pathological subtypes.
| Pathologic subtypes | 5-WT | EGFR+ | KRAS+ | ALK+ | RET+ | BRAF+ | 5-MT | total | P-value* | |
|---|---|---|---|---|---|---|---|---|---|---|
| All subtypes | N | 172 | 229 | 39 | 17 | 5 | 3 | 293 | 465 | - |
| % | 37.0% | 49.2% | 8.4% | 3.7% | 1.1% | 0.6% | 63.0% | 0.3276 | ||
| LPA | N | 3 | 15 | 3 | 1 | 0 | 0 | 19 | 22 | |
| % | 13.6% | 68.2% | 13.6% | 4.5% | 0.0% | 0.0% | 86.4% | |||
| IMA | N | 12 | 12 | 10 | 5 | 0 | 2 | 29 | 41 | < 0.0001 |
| % | 29.3% | 29.3% | 24.4% | 12.2% | 0.0% | 4.9% | 70.7% | |||
| APA | N | 40 | 75 | 8 | 4 | 1 | 0 | 88 | 128 | 0.5203 |
| % | 31.3% | 58.6% | 6.3% | 3.1% | 0.8% | 0.0% | 68.8% | |||
| PPA | N | 98 | 110 | 13 | 2 | 2 | 1 | 128 | 226 | 0.1923 |
| % | 43.4% | 48.7% | 5.8% | 0.9% | 0.9% | 0.4% | 56.6% | |||
| MPA | N | 6 | 3 | 1 | 0 | 0 | 0 | 4 | 10 | 0.7471 |
| % | 60.0% | 30.0% | 10.0% | 0.0% | 0.0% | 0.0% | 40.0% | |||
| SPA | N | 13 | 14 | 4 | 5 | 2 | 0 | 25 | 38 | 0.0207 |
| % | 34.2% | 36.8% | 10.5% | 13.2% | 5.3% | 0.0% | 65.8% | |||
| P-value$ | 0.0282 | 0.0025 | 0.0002 | 0.2271 | 0.0127 | 0.0136 | < 0.0001# |
WT: wild-type; MT: mutant; Bold font denotes the subtype with the highest mutation rate. Red color indicates statistical significance; *compared to all subtypes; $compared to all negative groups; #comparing all pathological subtypes and all genotypes.