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. 2017 Jul 19;8(47):82303–82313. doi: 10.18632/oncotarget.19398

Figure 3. c-Met, CREB1 and EGFR are direct miR-493-5p targets.

Figure 3

(A) Decreased CREB1 and EGFR expression was observed in miR-493-5p-transfected PC-3 and Du-145 cells via qRT-PCR. (B) Decreased c-Met, CREB1 and EGFR expression was observed in miR-493-5p-transfected PC-3 and Du-145 cells via western blot. (C) The miR-493-5p-targeting sites in c-Met, CREB1 and EGFR 3′-UTRs were mutated. (D) miR-493-5p significantly suppressed the luciferase activity of vector that carried the c-Met, CREB1 and EGFR 3′-UTRs but not control vector; Error bars represent the S.E. obtained from three independent experiments; *P<0.05.