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. 2017 Jul 27;8(47):82459–82474. doi: 10.18632/oncotarget.19614

Table 2. Enrichment for biological processes related to metabolism, catabolism & synthesis and immune function among functionally validated targets of miRNA that were differentially secreted via exosomes across all 4 HNSCC lines relative to those from non-pathologic oral epithelial cells.

GO biological process Enrichment p-value
Metabolism, Catabolism & Biomolecular Synthesis
Cellular nitrogen compound metabolic process 4.51E-132
Biosynthetic process 2.98E-100
Small molecule metabolic process 6.52E-33
Catabolic process 1.71E-24
Cellular lipid metabolic process 6.40E-18
Cellular protein metabolic process 3.16E-16
Glycosaminoglycan metabolic process 2.98E-11
Nucleobase-containing compound catabolic process 2.42E-10
Energy reserve metabolic process 1.34E-09
Chondroitin sulfate metabolic process 1.78E-05
Sulfur compound metabolic process 9.17E-05
mRNA metabolic process 1.05E-04
Hexose transport 4.99E-04
Vitamin metabolic process 5.19E-04
Generation of precursor metabolites and energy 7.34E-04
Water-soluble vitamin metabolic process 1.12E-03
DNA metabolic process 1.17E-03
Phospholipid metabolic process 1.56E-03
Glycerophospholipid biosynthetic process 2.22E-03
Nucleobase-containing small molecule metabolic process 2.42E-03
Regulation of glucose transport 2.95E-03
RNA metabolic process 2.95E-03
Glutamate secretion 4.09E-03
Regulation of insulin secretion 5.07E-03
Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 5.94E-03
Phosphatidylinositol biosynthetic process 8.03E-03
Inositol phosphate metabolic process 1.04E-02
Dolichol-linked oligosaccharide biosynthetic process 1.50E-02
Unsaturated fatty acid metabolic process 3.08E-02
Alpha-linolenic acid metabolic process 3.08E-02
Keratan sulfate metabolic process 4.32E-02
Regulation of cellular amino acid metabolic process 4.69E-02
Immune Function
Fc-epsilon receptor signaling pathway 1.42E-37
TRIF-dependent toll-like receptor signaling pathway 5.92E-27
Toll-like receptor 10 signaling pathway 1.08E-22
MyD88-independent toll-like receptor signaling pathway 1.25E-22
Toll-like receptor TLR1:TLR2 signaling pathway 1.46E-22
Toll-like receptor TLR6:TLR2 signaling pathway 1.46E-22
Fc-gamma receptor signaling pathway involved in phagocytosis 2.37E-19
Toll-like receptor 3 signaling pathway 2.91E-19
Toll-like receptor 5 signaling pathway 1.40E-18
Immune system process 4.31E-18
Toll-like receptor 9 signaling pathway 1.07E-17
Platelet activation 1.34E-17
Toll-like receptor 4 signaling pathway 3.60E-15
Toll-like receptor 2 signaling pathway 3.85E-14
Toll-like receptor signaling pathway 2.50E-13
MyD88-dependent toll-like receptor signaling pathway 4.31E-09
Platelet degranulation 8.94E-09
Leukocyte migration 1.02E-08
Innate immune response 1.59E-07
Antigen processing and presentation of exogenous peptide antigen via MHC class I 2.46E-07
Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent 3.80E-07
Antigen processing and presentation of exogenous peptide antigen via MHC class II 2.19E-06
Positive regulation of type I interferon production 1.49E-05
Negative regulation of type I interferon production 1.56E-03
Cytokine-mediated signaling pathway 3.24E-03
Antigen processing and presentation of peptide antigen via MHC class I 1.25E-02
Regulation of interferon-gamma-mediated signaling pathway 1.90E-02