Table 2. Association between the polymorphisms in the promoter of miR-17-92 and risk of CRC.
| SNPs | Controls (n = 1132) (%) | CRC (n = 874) (%) | Adjusted OR (95% CI) † | P value |
|---|---|---|---|---|
| rs9588884 | ||||
| CC | 350 (30.9) | 334 (38.2) | 1.00 (Ref) | |
| CG | 580 (51.2) | 450 (51.5) | 0.80 (0.66-0.98) | 0.03 |
| GG | 202 (17.8) | 90 (10.3) | 0.46 (0.35-0.62) | < 0.001 |
| Dominant model | 0.72 (0.59-0.86) | < 0.001 | ||
| Recessive model | 0.53 (0.40-0.69) | < 0.001 | ||
| rs982873 | ||||
| TT | 330 (29.2) | 280 (32.0) | 1.00 (Ref) | |
| TC | 582 (51.4) | 481 (55.0) | 0.98 (0.80-1.20) | 0.83 |
| CC | 220 (19.4) | 113 (12.9) | 0.60 (0.46-0.80) | < 0.001 |
| Dominant model | 0.88 (0.73-1.06) | 0.15 | ||
| Recessive model | 0.62 (0.49-0.80) | < 0.001 | ||
| rs1813389 | ||||
| AA | 371 (32.8) | 295 (33.8) | 1.00 (Ref) | |
| AG | 577 (51.0) | 462 (52.9) | 1.02 (0.83-1.24) | 0.88 |
| GG | 184 (16.3) | 117 (13.4) | 0.81 (0.61-1.06) | 0.13 |
| Dominant model | 0.96 (0.80-1.16) | 0.70 | ||
| Recessive model | 0.80 (0.62-1.03) | 0.08 |
CRC, colorectal cancer; SNP, single nucleotide polymorphism; OR, odd ratio; CI, confidence interval.
† adjusted by age and gender.