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. 2017 Jul 28;8(47):82609–82620. doi: 10.18632/oncotarget.19664

Figure 3. TIMP-1 expression is increased in BE(2)-C/LM2 subclone and host plasma.

Figure 3

Cytokine array analysis using murine plasma showed higher TIMP-1 levels in mice injected with BE(2)-C/LM2 cells when compared to BE(2)-C/Luc controls. (B) Increased plasma TIMP-1 expression in mice injected with BE(2)-C/LM2 cells was confirmed by murine TIMP-1-specific ELISA. (C) Endogenous tumor TIMP-1 secretion and expression was higher in BE(2)-C/LM2 cells in comparison to BE(2)-C/Luc parental cells as assessed by human TIMP-1-specific ELISA and immunoblotting, respectively. (D) Immunohistochemical analysis indicated a differential expression of TIMP-1 in the hepatic lesions of mice injected with BE(2)-C/Luc versus BE(2)-C/LM2 (arrows indicate tumor cells within the hepatic micrometastases; mean ± SEM; * =p< 0.05).