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. 2017 Jul 28;8(47):82609–82620. doi: 10.18632/oncotarget.19664

Figure 4. RNA interference of TIMP-1 blocks BE(2)-C/LM2 growth in vitro.

Figure 4

(A, B) TIMP-1 silencing by siRNA was confirmed by immunoblotting and human-specific TIMP-1 ELISA, respectively. (C) Silencing TIMP-1 decreased the proliferation rate of BE(2)-C/LM2 cells but not that of BE(2)-C/Luc cells. (D) Targeting TIMP-1 using siRNA inhibited anchorage-independent growth of BE(2)-C/LM2/siTIMP-1 cells in comparison to BE(2)-C/LM2/siNTC cells (mean ± SEM; *LM2 vs. Luc =p< 0.05; † LM2siNTC vs. LM2 siTIMP-1 = p<0.05).