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| Subgroup | No. of studies | Cases | Pooled OR | 95% CI | P value |
|---|---|---|---|---|---|
| Tumor stage (T3+T4/T1+T2) | 24 | 4769 | 1.87 | 1.64-2.12 | <0.0001 |
| Differentiation (poor/ well +moderate) | 14 | 3476 | 1.09 | 1.60-2.23 | <0.0001 |
| Clinical stage (III+IV/I+II) | 25 | 4734 | 1.96 | 1.69-2.27 | <0.0001 |
| Nodal metastasis (negative/ positive) | 12 | 2010 | 2.37 | 1.93-2.90 | <0.0001 |
