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. 2017 Aug 16;8(47):82803–82823. doi: 10.18632/oncotarget.20294

Figure 2. The effect of VEGF in glucose metabolism in AML cell lines.

Figure 2

Figure 2

1H-13C-HSQC NMR spectra of HL60 (A), THP1 (B) and HEL (C) intracellular extracts cultured with 13C-U-glucose in the absence and in the presence of 10μg/mL of VEGF. (D) 1H-NMR spectra highlight of the lactate methyl group when the three cell lines (HL60, THP1 and HEL) were cultured with 13C-U-glucose: in the absence (spectra below) and in the presence of VEGF (spectra above). The percentage of 13C-lactate and 12C-lactate present each condition is indicated in the board. Gluc- glucose; Ace- acetate; Glm- glutamine; Lac- lactate and NT- ribosyl moiety of nucleotides. Results were obtained from 3 independent replicates, and representative figures are presented.