Table 2. MCT1 and MCT4 cell localization in bone marrow (BM) of AML patients with M0- M5 (n=28) and M6/M7 (n=7) subypes.
| AML (M classification) |
Cells localization in BM | NE | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Para-trabecular | p value | Central | p value | Diffuse | p value | Negative | p value | |||
| MCT1 | M0-M5 | 64.3% (18/28) | 0.003 | 3.6% (1/28) | 0.464 | 21.4% (6/28) | 0.017 | 0% (0/28) |
- | 10.7% (3/28) |
| M6/M7 | 0% (0/7) |
14.3% (1/7) | 71.4% (5/7) |
0% (0/7) |
14.3% (1/7) | |||||
| Disease free BM | 60% (3/5) |
0.840 a 0.073 b |
0% (0/5) |
0.935 a 0.473 b |
40% (2/5) |
0.747 a 0.259 b |
0% (0/5) |
- | 0% (0/5) |
|
| MCT4 | M0-M5 | 17.9% (5/28) | 0.256 | 14.3% (4/28) | 0.022 | 53.6% (15/28) | 0.550 | 7.1% (2/28) | 0.748 | 7.1% (2/28) |
| M6/M7 | 0% (0/7) |
57.1% (4/7) | 28.6% (2/7) | 0% (0/7) |
14.3% (1/7) | |||||
| Disease free BM | 20% (1/5) |
0.999 a 0.659 b |
20% (1/5) |
0.970 a 0.150 b |
60% (3/5) |
0.995 a 0.668 b |
0% (0/5) |
0.779 a 1 b |
0% (0/5) |
|
AML patient subtypes were classified according to WHO classification. Disease free BM (n=5) were used as control. NE - not evaluated.
a) p value of M0-M5 vs Disease free BM; b) p value of M6/M7 vs Disease free BM.