Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Aug 7;8(47):82897–82909. doi: 10.18632/oncotarget.19970

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © 2017 Kampa-Schittenhelm et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PMC Copyright notice

Crenolanib displays distinct antiproliferative and proapoptotic effects of genetically altered Ba/F3 cells in dependence of the tyrosine kinase isoform (KIT D816V, A/C, or D816Y, B/D) transfected, whereas the parental Ba/F3 cells do not show significant proapoptotic activity (E), marking off-target toxicity >1000 nM. Transfection of a mutant-FLT3 ITD isoform renders cells highly sensitive towards crenolanib (F). Comparison of crenolanib versus dasatinib with regard to induction of apoptosis is shown (G). One-way ANOVA and Tukey’s honestly significant difference (HSD) tests are provided. Values in black indicate significance compared to the untreated controls.