Table 4. Multivariate analysis for survival of ER-positive breast cancer patients in the METABRIC dataset.

Factors	Disease-free survival			Overall survival
	HR	95% CI	p-value	HR	95% CI	p-value
AR/FOXA1
AR-low/FOXA1-low	Ref			Ref
AR-low/FOXA1-high	0.566	0.351 - 0.912	0.019	0.661	0.440 - 0.995	0.047
AR-high/FOXA1-low	0.775	0.468 - 1.283	0.322	0.992	0.651 - 1.511	0.969
AR-high/FOXA1-high	0.648	0.443 - 0.950	0.026	0.996	0.713 - 1.392	0.982
Age (≤ 50 years)	0.664	0.491 - 0.896	0.008	0.407	0.314 - 0.527	< 0.001
TNM stage
Stage I	Ref			Ref
Stage II	1.654	1.287 - 2.126	< 0.001	1.604	1.348 - 1.909	< 0.001
Stage III	3.940	2.830 - 5.484	< 0.001	2.766	2.148 - 3.562	< 0.001
Histologic grade (III)	1.561	1.282 - 1.901	< 0.001	1.239	1.075 - 1.429	0.003
HER2 (positive)	1.871	1.395 - 2.510	< 0.001	1.474	1.156 - 1.880	0.002
Chemotherapy (not done)	0.672	0.489 - 0.924	0.015	0.840	0.636 - 1.110	0.220
Endocrine therapy (not done)	1.067	0.826 - 1.379	0.619	0.960	0.802 - 1.148	0.651