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. 2017 Jul 26;8(47):82991–83008. doi: 10.18632/oncotarget.19635

Figure 2.

Figure 2

(A-B) miR-27a-3p inhibitor significantly suppressed cell proliferation (A) and clone formation (B) in HCT116. However, RXRα knockdown reversed the suppression of cell proliferation and clone formation in HCT116 induced by miR-27a-3p inhibitor. (C-D) miR-27a-3p mimic significantly increased cell proliferation (C) and clone formation (D) in SW480 compared with the control group. (E-F) miR-27a-3p inhibitor significantly induced cell apoptosis (E) and cell cycle G-S phase arrest (F) in HCT116. However, RXRα knockdown reversed elevated cell apoptosis in HCT116 induced by miR-27a-3p inhibitor. (G-H) miR-27a-3p mimic significantly suppressed cell apoptosis (G) and cell cycle G-S phase arrest (H) in SW480 compared with the control group.