Table 3. Post-treatment echocardiographic data.
Variables | Sham (n=15) |
AS (n=13) |
AS-GH (n=08) |
---|---|---|---|
BW (g) | 484 ± 42 | 415 ± 31* | 476 ± 58# |
LVDD (mm) | 7.73 ± 0.53 | 7.93 ± 1.42 | 7.98 ± 1.02 |
LVDD/BW (mm/kg) | 15.54 ± 1.45 | 18.47 ± 3.20* | 16.53 ± 3.62# |
LVSD (mm) | 3.16 ± 0.51 | 4.08 ± 1.74 | 3.20 ± 0.91 |
PWDT (mm) | 1.43 ± 0.09 | 2.25 ± 0.25* | 2.41 ± 0.37* |
PWST (mm) | 3.03 ± 0.21 | 3.79 ± 0.48* | 4.33 ± 0.63* |
IVSST (mm) | 2.80 ± 0.19 | 3.05 ± 0.26* | 3.44 ± 0.30*# |
IVSDT (mm) | 1.45 ± 0.08 | 2.26 ± 0.24* | 2.40 ± 0.35* |
AO (mm) | 3.9 ± 0.1 | 4.1 ± 0.2* | 4.0 ± 0.2 |
LA (mm) | 4.9 ± 0.2 | 7.0 ± 0.8* | 7.8 ± 1.2* |
LA/AO | 1.28 ± 0.06 | 1.74 ± 0.19* | 1.92 ± 0.30* |
LA/BW (mm/kg) | 9.89 ± 0.79 | 16.22 ± 1.68* | 15.87 ± 2.08* |
LVRWT | 0.37 ± 0.03 | 0.58 ± 0.10* | 0.62 ± 0.16* |
HR (bpm) | 303 ± 43 | 298 ± 27 | 308 ± 21 |
EFS (%) | 59.1 ± 5.6 | 49.8 ± 14.7* | 59.8 ± 12.1# |
MWFS (%) | 32.8 ± 3.2 | 26.6 ± 7.9* | 31.6 ± 6.3 |
LVEF | 0.93 ± 0.03 | 0.87 ± 0.10 | 0.92 ± 0.08 |
PWSV (mm/s) | 38.6 ± 7.2 | 25.2 ± 5.1* | 25.6 ± 3.1* |
E-wave | 74 ± 8.5 | 132 ± 15.7* | 121 ± 19.0* |
A-wave | 55 ± 15.9 | 26 ± 5.0* | 23 ± 5.8* |
E/A | 1.45 ± 0.37 | 5.23 ± 0.97* | 5.59 ± 1.31* |
EDT (ms) | 53 ± 4.3 | 33 ± 4.8* | 29 ± 5.9* |
IVRT (ms) | 33 ± 4.18 | 24 ± 4.70* | 21 ± 5.77* |
IVRTn (ms) | 34 ± 4.3 | 23 ± 5.0* | 21 ± 5.5* |
Data are expressed as mean ± standard deviation. AS: aortic stenosis; AS-GH: aortic stenosis treated with growth hormone; n: number of animals; ; LVDD and LVSD: left ventricle (LV) diastolic and systolic diameters, respectively; PWDT and PWST: LV posterior wall diastolic and systolic thicknesses, respectively; IVSST and IVSDT: interventricular septum systolic and diastolic thicknesses, respectively; AO: aortic diameter; LA: left atrial diameter; LVRWT: LV relative wall thickness; HR: heart rate (beats/min); EFS: endocardial fractional shortening; MWFS: midwall fractional shortening; LVEF: LV ejection fraction; PWSV: LV posterior wall shortening velocity; E/A: early-to-late diastolic mitral inflow ratio; EDT: E-wave deceleration time; IVRT: isovolumetric relaxation time; IVRTn: IVRT normalized to heart rate. ANOVA and Tukey; * p<0.05 vs Sham; # p<0.05 vs AS.