Table 2. Associations between lncRNA levels and lung cancer clinicopathologic characteristics.
| Characteristic | Number of studies | Pooled RR (95% CI) |
P | Heterogeneity test | References | |
|---|---|---|---|---|---|---|
| I2 | P | |||||
| Age (> 50 vs ≤ 50) |
3 | 1.086 (0.907,1.301) | 0.370 | 0.0% | 0.823 | 32, 41, 42 |
| (> 55 vs ≤ 55) | 3 | 1.057 (0.874,1.277) | 0.570 | 0.0% | 0.985 | 28, 29, 43 |
| (> 60 vs ≤ 60) | 7 | 1.013 (0.868,1.182) | 0.871 | 0.0% | 0.654 | 16, 19, 21, 22, 24, 33, 36 |
| (> 65 vs ≤ 65) | 6 | 0.992 (0.822,1.198) | 0.937 | 0.0% | 0.825 | 14, 17, 20, 26, 27, 38 |
| Gender (male vs female) |
19 | 0.983 (0.906,1.066) | 0.682 | 0.0% | 0.834 | 14, 16, 17, 19, 20, 21, 22, 24, 26, 27, 28, 29, 32, 33, 36, 38, 41, 42, 43 |
| Histological grade (poor vs well) |
8 | 0.951 (0.689,1.312) | 0.759 | 70.1% | 0.001 | 16, 18, 19, 22, 27, 28, 30, 36 |
| Histological classification (SCC vs AD) |
11 | 1.013 (0.891,1.153) | 0.839 | 35.0% | 0.119 | 14, 18, 20, 15, 26, 17, 27, 29, 30, 36, 38, |
| Tumour size (> 3 vs ≤ 3) |
11 | 1.181 (0.883,1.580) | 0.262 | 74.9% | 0.000 | 15, 16, 18, 21, 22, 24, 27, 28, 29, 30, 33, 36 |
| (> 5 vs ≤ 5) | 6 | 1.313 (0.904,1.905) | 0.152 | 82.0% | 0.000 | 14, 17, 20, 26, 38, 41 |
| TNM Stage (III/IV vs I/II) |
13 | 1.339 (1.046,1.716) | 0.012 | 86.5% | 0.000 | 14, 15, 16, 17, 18, 19, 20, 21, 22, 24, 26, 27, 28, 30, 32, 33, 38 |
| Lymph node metastasis (positive vs negative) |
20 | 1.442 (1.103,1.885) | 0.007 | 86.7% | 0.000 | 14, 15, 16, 17, 18, 19, 20, 21, 22, 26, 27, 28, 29, 30, 32, 33, 38, 41, 42, 43 |
| Distant metastasis (yes vs no) |
4 | 3.187 (1.393,7.294) | 0.006 | 83.8% | 0.000 | 32, 41, 42, 43 |
| Smoking status (yes vs no) |
18 | 1.040 (0.918,1.179) | 0.536 | 58.6% | 0.001 | 14, 16, 17, 18, 19, 20, 22, 24, 26, 27, 28, 30, 32, 36, 38, 42, 43 |