Table 1.

Characteristics of available observational studies meeting high quality standards addressing the spontaneous reversion of mild cognitive impairment (MCI).

Reference	Setting	n	Sex (%F)	Mean age	Follow-up (years)	MCI definition	Reversion (%)
Grande et al. (15)	C	374	60.2	75.1 ± 6.9	2.7 ± 2.1	IWG	5.6
Roberts et al. (16)	P	534	44.6	na	5.1	IWG	37.6
Sachdev et al. (17)	P	320	51.1	11.5 ± 0.8a	1.9 ± 0.1	IWG	20.6
Manly et al. (18)	P	564	68.0	76.5 ± 1.3a	5	Mayo Clinic	30.1
Pérès et al. (19)	P	285	57.2	na	2	Mayo Clinic	21.4
Larrieu et al. (20)	P	58	na	na	2	Mayo Clinic	41.4

Modified from Ref. (13).

C, clinical-based study; P, population-based study; na, not available; IWG, International Working Group criteria for MCI; Mayo, Mayo Clinic criteria for MCI.

^aWeighted mean values.

In the present table, we report the six studies of “better quality,” defined using the Quality in Prognostic Studies tool (21), included in a previous meta-analysis on the topic (13).