FIGURE 2.
Positions of the studied mutations in CPR. The structure of the yeast-human open form CPR chimera (3FJO, in dark green) and the WT soluble human closed form CPR (5FA6, chain A, in pink) were used to analyze the variations in the hinge segment between the closed and open form of CPR. Mutated residues are displayed as sticks of either green or magenta colors according to the structures. (A) Both structures were aligned onto their FMN domains. (B) Both structures were aligned onto their connecting/FAD domains. The figure was prepared using the PyMol software (Schrödinger, 2015).