FIGURE 5.
Hydrogen bond network around residue R246 of human CPR. (A) Position of R246, Q247, D445 and E449 in the structure of the soluble form of WT human CPR. The color coding is as follows: FMN domain, cyan; hinge segment, green; connecting domain, orange; FAD domain, red. Flavins are depicted in yellow sticks, the various positions as stick in the same color code of the domain to which they belong. (B) Detailed view of the hydrogen bonding network. The color coding is the same as in (A).