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. 2017 Nov 3;7:14487. doi: 10.1038/s41598-017-13751-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Screening results of the aptamer candidates against cell-SELEX cell lines using flow cytometry. (A) Screening results of MGB2 aptamers show six aptamers out of twelve (MAMB0, MAMB1, MAMB4, MAMB8, MAMB12, MAMB57) with higher fluorescence intensity in the target selection cell line than counter selection ones. (B) Screening results of MGB1 aptamers show four aptamers out of eight (MAMA2, MAMA5, MAMA6, and MAMA12) with higher fluorescence intensity in the target selection cell line than counter selection ones. Promising aptamers were chosen for further studies. The experiments were repeated twice. Values are shown as means ± S.E.M.