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. 2017 Nov 3;7:14490. doi: 10.1038/s41598-017-12683-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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3D HKC-8 spheroids response to nephrotoxic compounds. (a) Schematic diagram of the HKC-8 spheroid response to nephrotoxins, (b) Quantitative image analysis of HKC-8 spheroids disease response by monitoring different reporter constructs (left, HKC-8 E-cadherin GFP; right, HKC-8 CycleTrak, n ≥ 4) (c) Kidney molecular tox gene panels consisting of ~1600 relevant genes analysis of the HKC-8 spheroids response to nephrotoxins (*P < 0.1, **P < 0.01; n.s., not significant (Mann Whitney U test). AA and cyclosporine A concentrations are 125 μM and 1.5 μM, respectively. For each group, spheroids were pooled from ~45,000 seeded cells. Scale bar, 30 μm (b).