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Funnel plot of mean difference in weekly stool frequency with probiotics vs. controls. Egger’s P-value is <0.01, suggesting significant publication bias. Open circles represent observed values; shaded circles represent trim-and-fill adjusted values. Pooled estimate for observed values is 0.83 (95% confidence interval [CI] 0.53-1.14), represented by an open diamond. Pooled estimate for trim-and-fill adjusted values is 0.30 (95%CI -0.01 to 0.62), represented by a shaded diamond
