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. 2017 Oct 30;8:849. doi: 10.3389/fphys.2017.00849

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Copyright © 2017 Liu, Lu, Xu, Atzberger, Günther, Wettschureck and Offermanns.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Generation of Tas2r143-CreERT2 transgenic mice. (A) NanoString analysis of mRNA expression levels for bitter taste receptors in the murine heart. (n = 2, error bars represent mean ± SD). (B) The genomic sequence between the start codon of Tas2r143 and the stop codon of Tas2r126 (35.2 kb) on BAC RP23-316O11 was replaced by a cassette carrying the CreERT2 cDNA followed by a polyadenylation (pA) signal. (C,D) Offspring of transgenic mice was genotyped by genomic PCR with primers P1/P2 and P3/P4 identifying a 614 bp and a 418 bp fragment, respectively, which indicate the correctly inserted CreERT2.