. 2017 Oct 30;8:301. doi: 10.3389/fendo.2017.00301

Table 1.

Body weight outcomes of dams treated with OFS, S, both, or neither and their offspring.

	Lean-Control	Obese-HFS	Obese-Control	Obese-OFS	Obese-S	Obese-OFS + S
Dams
Baseline weight (g)	306 ± 7^a	339 ± 10^b	332 ± 7^ab	331 ± 5^ab	329 ± 5^ab	332 ± 5^ab
Intervention weight change (g)	18.5 ± 4.3^ab	35.5 ± 6.6^a	18.9 ± 5.4^ab	12.1 ± 5.5^b	13.0 ± 4.0^b	−6.1 ± 4.4^c
Weight at breeding (g)	324 ± 6^b	377 ± 14^a	348 ± 7^ab	339 ± 7^b	347 ± 9^ab	323 ± 7^b
Pregnancy weight change (g)	125 ± 7^ac	131 ± 5^a	85 ± 11^b	94 ± 10^bc	117 ± 7^ac	90 ± 10^b
Lactation weight change (g)	15.9 ± 3.7^ab	0.3 ± 9.2^ab	10.2 ± 15.5^ab	10.9 ± 5.1^ab	−21.9 ± 9^a	2.3 ± 10.8^ab

Offspring
Male birth weight (g)	7.2 ± 0.4	7.3 ± 0.4	6.9 ± 0.3	8.3 ± 0.4	7.4 ± 0.4	6.9 ± 0.6
Female birth weight (g)	7.2 ± 0.2^ab	7.1 ± 0.3^ab	6.7 ± 0.2^a	7.7 ± 0.3^ab	7.3 ± 0.3^ab	8.0 ± 0.3^b
Male weaning weight (g)	60 ± 4.9	60.9 ± 5.7	51.6 ± 7	51.8 ± 5.4	58.7 ± 5.2	53.4 ± 5.2
Female weaning weight (g)	56 ± 5	45.8 ± 7.2	38.5 ± 5.5	50.3 ± 5.5	55.3 ± 5.3	51.7 ± 5.3

Values are presented as mean ± SEM (n = 11–13 per group).

HFS, high fat/sucrose; OFS, oligofructose; S, sitagliptin.

Obese in the group name indicates diet-induced obese rats that underwent the respective prepregnancy interventions, except Obese-HFS that remained untreated and consumed HFS diet throughout the study. Lean in the group name indicates a lean reference group that never underwent the obesity induction period and consumed control AIN-93 diet throughout the study. Baseline weight refers to body weight after the obesity induction period and just before starting the diet and drug preconception treatments. Mean values with different superscripts are significantly different between treatment groups (p < 0.05). For example, a group with “^a” is significantly different from a group with “^b” but not from a group with “^ab.”