Table 2.
Reproductive parameters of dams treated prepregnancy with OFS, S, both, or neither.
| Lean-Control | Obese-HFS | Obese-Control | Obese-OFS | Obese-S | Obese-OFS + S | |
|---|---|---|---|---|---|---|
| Mated rats | 13/13 (100%) | 12/12 (100%) | 13/13 (100%) | 12/12 (100%) | 13/13 (100%) | 12/12 (100%) |
| Fertility index | 13/13 (100%) | 10/12 (83.3%) | 13/13 (100%) | 10/12 (83.3%) | 13/13 (100%) | 12/12 (100%) |
| Delivery index | 10/13 (76.9%) | 10/10 (100%) | 11/13 (84.6%) | 9/10 (90.0%) | 11/13 (84.6%) | 9/12 (75.0%) |
| Pregnancy index | 9/13 (69.2%) | 8/10 (80.0%) | 11/13 (84.6%) | 8/10 (80.0%) | 10/13 (76.9%) | 8/12 (66.7%) |
| Litter size (# live at birth) | 10.3 ± 1.5 | 7.14 ± 1.3 | 8.5 ± 1.5 | 11.1 ± 1.2 | 8.33 ± 0.8 | 6.57 ± 1.1 |
| Pup survival (% live at 2 weeks) | 82.5 | 63.7 | 57.4 | 64.4 | 82.7 | 81.0 |
| Sex prevalence (% males) | 38.1 | 51.6 | 51.6 | 40.4 | 50.4 | 51.1 |
Values are presented as mean ± SEM (n = 11–13 per group).
HFS, high fat/sucrose; OFS, oligofructose; S, sitagliptin.
Obese in the group name indicates diet-induced obese rats that underwent the respective prepregnancy interventions, except Obese-HFS that remained untreated and consumed HFS diet throughout the study. Lean in the group name indicates a lean reference group that never underwent the obesity induction period and consumed control AIN-93 diet throughout the study. No statistically significant differences exist between maternal treatment groups (p ≥ 0.05).