Table 6.

Female offspring gut microbiota at 11 and 17 weeks.

	Week	Lean-Control	Obese-HFS	Obese-Control	Obese-OFS	Obese-S	Obese-OFS + S	Time	Txt	Time × Txt
Bacteroides/Prevotella	11	12.9 ± 1.6	7.5 ± 0.6	13.2 ± 1.1	12.4 ± 2.6	16.7 ± 1.8	10.5 ± 2.0	0.984	0.003	0.911
	17	12.3 ± 1.1	9.0 ± 1.1	12.7 ± 1.8	10.8 ± 1.7	14.7 ± 2.2	11.8 ± 3.0
Bifidobacterium	11	2.4 ± 0.8	1.9 ± 0.6	1.8 ± 0.8	1.1 ± 0.2	1.7 ± 0.3	2.9 ± 0.9	0.001	0.354	0.248
	17	0.59 ± 0.23	0.09 ± 0.03	0.40 ± 0.10	0.13 ± 0.05	0.10 ± 0.02	0.19 ± 0.04
Methanobrevibacter	11	0.07 ± 0.01	0.10 ± 0.02	0.09 ± 0.01	0.08 ± 0.02	0.06 ± 0.01	0.07 ± 0.01	0.024	0.989	0.221
	17	0.07 ± 0.01	0.05 ± 0.01	0.05 ± 0.01	0.05 ± 0.01	0.07 ± 0.01	0.07 ± 0.01
Enterobacteriaceae	11	0.36 ± 0.22	0.10 ± 0.04	0.02 ± 0.01	0.04 ± 0.01	0.02 ± 0.003	0.09 ± 0.02	0.863	0.080	0.969
	17	0.23 ± 0.21	0.04 ± 0.01	0.09 ± 0.03	0.05 ± 0.02	0.05 ± 0.02	0.07 ± 0.02
Lactobacillus	11	7.2 ± 2.2	8.4 ± 2.1	7.8 ± 2.6	4.1 ± 1.5	5.8 ± 0.7	5.9 ± 1.7	0.001	0.530	0.330
	17	3.5 ± 2.2	1.1 ± 0.3	2.6 ± 1.1	1.3 ± 0.4	1.4 ± 0.8	1.7 ± 0.6
Clostridium coccoides	11	26.6 ± 3.5	23.0 ± 2.7	22.3 ± 3.2	27.2 ± 4.1	18.5 ± 2.5	22.6 ± 3.3	0.496	0.316	0.182
	17	19.4 ± 2.4	32.0 ± 5.3	23.1 ± 4.1	24.7 ± 2.9	22.7 ± 1.9	28.9 ± 3.3
Clostridium leptum	11	10.6 ± 2.0	6.3 ± 1.1	6.4 ± 1.2	7.4 ± 1.7	9.8 ± 1.5	7.5 ± 0.9	0.001	0.218	0.781
	17	16.0 ± 2.5	12.2 ± 2.4	9.4 ± 2.7	16.3 ± 3.1	11.7 ± 2.1	13.0 ± 3.2
Clostridium cluster XI	11	0.03 ± 0.005	0.07 ± 0.02	0.03 ± 0.004	0.03 ± 0.004	0.02 ± 0.004	0.05 ± 0.02	0.003	0.442	0.658
	17	0.16 ± 0.05	0.21 ± 0.09	0.19 ± 0.07	0.11 ± 0.06	0.04 ± 0.02	0.17 ± 0.06
Clostridium cluster I	11	0.54 ± 0.09	0.81 ± 0.18	0.71 ± 0.10	0.46 ± 0.08	0.75 ± 0.04	0.73 ± 0.18	0.001	0.417	0.714
	17	0.03 ± 0.01	0.06 ± 0.05	0.05 ± 0.01	0.01 ± 0.002	0.03 ± 0.01	0.05 ± 0.02
Roseburia	11	0.02 ± 0.01	0.02 ± 0.01	0.01 ± 0.002	0.01 ± 0.003	0.01 ± 0.004	0.01 ± 0.004	0.323	0.285	0.198
	17	0.02 ± 0.01	0.01 ± 0.005	0.03 ± 0.02	0.01 ± 0.004	0.01 ± 0.004	0.01 ± 0.004

Values are mean ± SEM (n = 8–11) expressed as the relative abundance (%) of bacterial taxa per total bacteria (16S rRNA gene copies of microbial group/total bacteria 16S rRNA gene copies). Week 11 represents values just before starting the high fat/sucrose (HFS) diet whereas week 17 represents values after 6 weeks of HFS diet.

Txt, treatment.