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. 2017 Nov 3;18:185. doi: 10.1186/s12931-017-0668-9

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Schematic flow chart (a) and timeline of study design (b). C group: intratracheal instillation of 50 μL of saline, ELA: intratracheal instillation of 0.2 UI of pancreatic porcine elastase (PPE) once a week during 4 weeks, Sal: i.p. injection of saline (50 μL), Ghr: i.p. injection of ghrelin (200 μg kg^-1 per day)