Table 1.
Lung mechanics and morphometry
| C | ELA | |||
|---|---|---|---|---|
| Sal | Ghr | Sal | Ghr | |
| Lung mechanics | ||||
| Est,L (cmH2O mL-1) | 41.8±12.8 | 37.6±4.7 | 18.7±2.6* | 23.3±4.7# |
| Lung morphometry | ||||
| Lm (μm) | 40.2±1.6 | 40.8±1.1 | 67.4±2.2* | 50.4±1.9# |
| Normal (%) | 99.1±0.2 | 98.8±0.8 | 49.5±1.7* | 84.3±1.1# |
| Collapse (%) | 0.9±0.0 | 1.2±0.8 | 19.3±2.0* | 5.9±1.0# |
| Hyperinflation (%) | 0.0±0.0 | 0.0±0.0 | 31.2±1.6* | 9.8±1.4# |
| Mononuclear cells (%) | 32.2±1.2 | 32.3±1.5 | 47.7±0.8* | 37.3±1.4# |
| Neutrophils (%) | 1.9±0.4 | 1.8±0.2 | 7.4±0.7* | 2.2±0.5# |
Values are mean ± SD of 10 animals in each group. C control, ELA elastase-induced emphysema, Sal i.p. injection of saline, Ghr i.p. injection of ghrelin, Est,L static lung elastance; fractional area of normal alveoli, collapsed alveoli, lung hyperinflation, mononuclear cells and neutrophils. *Significantly different from C-Sal (P<0.05). #Significantly different from ELA-Sal (P<0.05)